There is no doubt that the future of genealogical research is molecular genealogy. The science of examining the bits and pieces of your DNA to figure out where you fit in the human gene pool is popping up everywhere from Ancestry.com to fully dedicated testing sources like FamilyTreeDNA.com.
Every person on earth has DNA which consists of 46 chromosomes (22 pairs of autosomes and 1 pair of sex chromosomes). Autosomal DNA is the hodge podge mixture of chromosomes that we inherit from both the maternal and paternal line and to which both males and females pass on in some random nature to their children. The X chromosome is passed from mother to children and from father to daughters. The Y chromosome is passed only from father to son and stays essential the same between generations. We also inherit Mitochondrial DNA (mtDNA) which is passed through the maternal line to children of both sex and also stays essentially the same.
DNA is probably one of the trickiest tools to get your mind around in genealogy research. As the above overview shows, we have four types of DNA and all of them can be matched to where we genetically come from. There is nothing inclusive or exclusive about it. We all have it and 99.9 % of it is the same in all of us and the small part that isn’t the same is shared in some way by many of us.
Where many get lost is when the really useful parts of the science comes in for genealogists. Not only do we have all of those chromosomes plus mitochondrial DNA, each chromosome is further magnified into small pieces which is where markers come in to help indentify haplogroups which can in theory show where your ancestors came from.
While haplogroups are interesting, they’re not going to help you indentify whether your great-great uncles kid is another researchers great great grandfather or help you add cousins that someone living could possibly have heard rumor of the existence of.
What I feel to be the true value of DNA in family history research is the connections you can find with more recent generations. Each test offers a difference scope and each has their own shortcomings. You can trace your direct paternal line (Father to grandfather to great-grandfather, etc) with the Y chromosome test, you can verify if someone is your sibling with an X chromosome test, you can find links to your maternal line with a mtDNA test and very soon you will be able to put your autosomes to use to track down cousins from both maternal and paternal lines.
Family Tree DNA, a company that has for many years been the go-to place for genealogical DNA testing has added a new test to their arsenal. Their new Family Finder kit will use autosomal DNA, those 22 matched pairs that contain DNA from everyone that has had anything to do with genetic makeup, to match customers with cousins up to five generations back with relative certainty. Five generations is an amazing range to work within. With mtDNA and Y DNA, you are essentially hunting ancestors with a spear… a direct line. With autosomal DNA testing it’s like fishing with a net.
Bennett Greenspan is the president and CEO of Family Tree DNA and has assembled a team of geneticists and molecular anthropologists to help out family historians in locating ancestors that would be potentially difficult without the use of science. Mr. Greenspan was generous enough to be interviewed by geneacentric.com on the relationship between DNA and genealogy and on his companies new product Family Finder which will be available in the coming weeks.
MH: How long have you been in the DNA business and what inspired you to bring together DNA and genealogy?
BG: I have been an amateur Genealogist for over 40 years and in 1999 I was researching my mother’s mother’s father’s line and I hit a paper trail roadblock I wasn’t able to get beyond…I recalled that the Y chromosome had been used to prove that a male Jefferson was related to a slave of issue from Thomas Jefferson’s wife’s 1/2 sister and that the proof was provided by testing the Y chromosome…I also recalled the use of the Y in testing men who claimed to be Cohanim, in theory decedents of Aaron, the brother of Moses. I conducted a proof of concept in 1999 and in April of 2000 I began selling Y and in June, mtDNA testing for Genealogical lineage confirmation.
MH: Genealogical DNA testing is something fairly new, at least in mainstream genealogical circles. I became familiar with the idea several years ago after reading an article on the Y chromosome testing of Thomas Jefferson and Sally Hemings’s descendents.
BG: That was the first MAJOR study that electrified the world (or Americans) and got us thinking of DNA testing in general. As I say it took me 18 months to figure out that I, as a lowly genealogist, could use this technology for my personal purposes.
MH: Why should family historians explore their ancestral DNA?
BG: Everyone runs into a paper trail roadblock eventually. So when the paper trail doesn’t exist, OR when you have questions about the accuracy of the documentation you can use DNA as a secondary source of that confirmation.
MH: In the Jefferson/Hemings case, there is much debate about whether Hemings are descended from Jefferson or one of his other male relatives. Is DNA testing accurate enough to more easily pinpoint an exact ancestor now than in the late 1990s when this test was performed?
BG: No, Y DNA testing can’t determine WHICH Jefferson male was the father of the one slave child of Sally Hemings, but Y DNA testing for sure has been able to confirm that some Jefferson male was with Sally Hemings.
MH: What can DNA testing not do? I imagine a lot of people go into the process thinking that they’re going to be greeted with a list of relatives that they can easily implement into their research. Is it more likely that they’ll find connections that will take a while to work out?
BG: Yes and no. Yes they will find relatives to the extent that our very large Y DNA database has male or female relatives along the direct Y or mtDNA lineages. Of course you will also find (i.e.) men who have the same last name and you can’t initially figure out how they are related, but that is what genealogy is all about. At least by using a DNA test you can easily determine that two men are NOT related, despite having the same last name, and therefore this can save you from wasting a lot of valuable time.
MH: Do you recommend DNA testing for those new to genealogy?
BG: I don’t suggest DNA testing as a substitute but in conjunction with conventional paper trial genealogy.
MH: Should those that are interested put in the time to work their family lines back four or five generations back?
BG: That could be a huge waste of time if the theory that someone is working is wrong…using the DNA as a first filter can save hours or years of wasted research.
MH: My blog focuses, in theory, on being a family historian that still has several living generations to work with. My great grandmother, for instance, just turned 90 years old a few months back. For those of us fortunate enough to have great grandparents around would having them participate in a DNA project be worthwhile?
BG: Yes, especially on the male side (and with our new Family Finder product) if you are only looking at a direct male or female line. If you have other direct relatives it is not essential to test the oldest family members, but using the Family Finder you can gain another generation or two by testing older relatives.
MH: Will doing so provide better results if both me and my great-grandmother take the mtDNA test?
BG: There is no reason for two close family members who share the same Y or mtDNA to test (except for using Family Finder since the autosomal signal is reduced by 50% in each generation).
MH: Family Tree DNA’s new product is called Family Finder. What is the difference between this test and the Y chromosome and mtDNA tests that your company has become well known for?
BG: Family Finder uses Autosomal DNA and looks for matching HAPLOBLOCKS between two people that is indicative of a common ancestry. Therefore for lineages that have daughters but no sons the comparison can now be made with Family Finder to show relatedness in ways that we have only dreamed of for the past 10 years.
MH: In the FAQ for Family Finder it is mentioned that the test is most accurate up to five generations back.
BG: Over time the HAPLOBLOCKS get ‘chopped’ up in the recombination process and we feel that a meaningful signal is lost after about the 5th cousin level.
MH: Going back to my own family, would there be any benefit to having my 90 year old great-grandmother take the new autosomal DNA test?
BG: By testing your grandmother you can get to HER 5th cousin which would be potentially a 7th cousin for you.
MH: Where does DNA testing go from here?
BG: Next stop: Full Genome when the price becomes reasonable for the general public.
MH: Between Y chromosome, mtDNA and autosomal chromosome testing it seems that we’re out of chromosome’s to test and compare. Is it now more of an effort to gain accuracy in testing and to grow the number of samples in the databases to be compared?
BG: Accuracy is there, it’s the larger and larger database for comparative purposes that we are still seeking.
MH: What is the rough estimate of the number of DNA samples in the various databases that family historians have to compare their own to?
BG: 300-400 thousand in my best guess. Only Family Tree DNA states the size of the database. Others do not presumably because they don’t compare well with our vast database.
MH: I think the thing that holds many family historians off from having the various DNA tests done is the cost. The costs have certainly gone done in the last few years and companies like your own offer several tests that many could afford. What would you say to the potential customers that are weighing the cost of the test with the potential return on investment?
BG: A one night hotel stay to look at courthouse records is priced the same as a DNA test. Plus gas, and TIME…something that is a gift that will not last forever. By that definition DNA testing is cheap.
MH: Is there a test that tends to produce more results than another?
BG: For men the Y is still by far the best way to find relatives going back 2-400 years on the direct name lineage.
MH: When can we expect to see the new Family Finder test available?
BG: Mid April is my best guess. Could be a few weeks earlier or perhaps a little later depending on the volumes we sustain in our Phase I rollout. The cost will be higher than our introductory price, but not substantially higher.
MH: Will there be a super-test option that combines the Y, mtDNA and autosomal tests?
BG: Yes, certainly there will be.
MH: Thank you for your time and I personally look forward to trying out the new offering from Family Tree DNA.
BG: Best regards.
I would like to thank Bennett Greenspan for taking the time to participate in this interview. I will be testing the new Family Finder product in the next couple of months and will post a full report with my experiences. If you have participated in genealogical DNA testing, what have your experiences been and do you plan on seeing what autosomal DNA test will add to your family tree?